NCLEX Medication Administration Exam Practice Questions and Answers

150 Questions and Answers

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Master one of the most critical areas of nursing with this comprehensive set of NCLEX Medication Administration Exam Practice Questions and Answers. Designed to reflect the latest NCLEX-RN and NCLEX-PN exam standards, this practice test covers every essential aspect of safe and effective medication administration.

This resource offers a variety of NCLEX-style questions, including multiple-choice, “select all that apply,” fill-in-the-blank (dosage calculation), and priority-setting scenarios to prepare you for the real exam. You’ll review key topics such as the “Five Rights” of medication administration, dosage conversions, pharmacokinetics, pharmacodynamics, routes of administration, and the prevention of medication errors.

Each question includes a detailed rationale to help you understand not just the correct answer, but also the clinical reasoning behind it. These explanations reinforce safe nursing practices and help sharpen your test-taking strategies, critical thinking, and clinical judgment.

Whether you’re studying for the NCLEX-RN or NCLEX-PN, these NCLEX Medication Administration Exam Practice Questions and Answers are tailored to help you build confidence and accuracy in one of the highest-risk areas of nursing care. This practice exam is ideal for nursing students, new graduates, or anyone preparing for licensure who wants to ensure thorough preparation for medication-related questions on the NCLEX.

Sample Questions and Answers

What is the primary purpose of a medication order?

a) To ensure patient safety
b) To confirm medication availability
c) To record the medication prescribed
d) To request medication refill

Answer: a) To ensure patient safety

A nurse is administering a medication via a nasogastric tube. Which action should the nurse take first?

a) Check the patient’s identification
b) Flush the tube with water
c) Crush the medication
d) Verify the placement of the tube

Answer: d) Verify the placement of the tube

Which of the following should be monitored when a patient is taking warfarin (Coumadin)?

a) Hemoglobin levels
b) International normalized ratio (INR)
c) Platelet count
d) Potassium levels

Answer: b) International normalized ratio (INR)

When administering a subcutaneous injection, what is the correct needle angle?

a) 15 degrees
b) 30 degrees
c) 45 degrees
d) 90 degrees

Answer: c) 45 degrees

Which of the following medications is considered a high-alert medication?

a) Acetaminophen
b) Insulin
c) Lorazepam
d) Omeprazole

Answer: b) Insulin

What should a nurse do if a patient refuses to take a prescribed medication?

a) Administer the medication regardless of refusal
b) Document the refusal and inform the healthcare provider
c) Try to convince the patient to take the medication
d) Notify the patient’s family about the refusal

Answer: b) Document the refusal and inform the healthcare provider

Which medication is used as a first-line treatment for hypertension?

a) Furosemide (Lasix)
b) Lisinopril (Zestril)
c) Atorvastatin (Lipitor)
d) Digoxin (Lanoxin)

Answer: b) Lisinopril (Zestril)

What is the most common side effect of opioid analgesics?

a) Nausea
b) Constipation
c) Drowsiness
d) Diarrhea

Answer: b) Constipation

Which of the following is a contraindication for administering acetaminophen (Tylenol)?

a) Liver disease
b) Kidney disease
c) Asthma
d) Hypertension

Answer: a) Liver disease

What should the nurse do before administering a dose of medication via IV route?

a) Verify the patient’s identity and allergies
b) Check the patient’s blood pressure
c) Assess the intravenous site for redness
d) Check the expiration date of the medication

Answer: a) Verify the patient’s identity and allergies

A patient is receiving chemotherapy. Which of the following is an important consideration when administering chemotherapy drugs?

a) The patient should have a full stomach
b) The nurse must wear personal protective equipment (PPE)
c) Chemotherapy drugs are given only in the morning
d) The patient should be encouraged to exercise

Answer: b) The nurse must wear personal protective equipment (PPE)

What is the first action the nurse should take when an error in medication administration is identified?

a) Notify the healthcare provider
b) Document the error in the patient’s chart
c) Assess the patient for any adverse effects
d) Discontinue the medication immediately

Answer: c) Assess the patient for any adverse effects

Which of the following is an example of a medication that should not be crushed?

a) Aspirin
b) Enalapril
c) Enteric-coated tablets
d) Acetaminophen

Answer: c) Enteric-coated tablets

What is the correct method of administering an intramuscular (IM) injection in an adult?

a) 45-degree angle
b) 60-degree angle
c) 90-degree angle
d) 15-degree angle

Answer: c) 90-degree angle

Which medication is contraindicated for a patient with a history of anaphylaxis to penicillin?

a) Amoxicillin
b) Clindamycin
c) Erythromycin
d) Doxycycline

Answer: a) Amoxicillin

What is the correct action for the nurse when administering a liquid medication to a child?

a) Measure the dose using a tablespoon
b) Use a calibrated dropper or oral syringe
c) Ask the child to drink the medication directly from the bottle
d) Mix the medication with water before administration

Answer: b) Use a calibrated dropper or oral syringe

A nurse is preparing to administer a medication intravenously. What is the first step the nurse should take?

a) Verify the patient’s ID
b) Inspect the IV site
c) Verify the physician’s order
d) Prepare the medication

Answer: c) Verify the physician’s order

Which of the following best describes the “right time” when administering medications?

a) Administering medications within 30 minutes before or after the scheduled time
b) Administering medications as early as possible
c) Administering medications after checking the patient’s temperature
d) Administering medications after the physician’s office visit

Answer: a) Administering medications within 30 minutes before or after the scheduled time

What is the most important factor when administering a medication via a patient-controlled analgesia (PCA) pump?

a) Verifying the drug dosage with the patient
b) Ensuring the patient is educated on PCA use
c) Monitoring the patient’s blood pressure continuously
d) Ensuring the patient has a high fluid intake

Answer: b) Ensuring the patient is educated on PCA use

Which of the following is a common side effect of antihistamines?

a) Drowsiness
b) Insomnia
c) Diarrhea
d) Tachycardia

Answer: a) Drowsiness

What is the nurse’s responsibility before administering a medication?

a) Ask the patient if they are allergic to any medications
b) Observe the patient for any side effects from previous medications
c) Verify the medication order, patient identity, and drug
d) Inform the family about the medication schedule

Answer: c) Verify the medication order, patient identity, and drug

Which medication would be most appropriate for treating a patient with a bacterial infection?

a) Acetaminophen
b) Amoxicillin
c) Lorazepam
d) Diphenhydramine

Answer: b) Amoxicillin

A patient is prescribed a medication that is a teratogen. Which of the following should be done before administration?

a) Ensure the patient is not pregnant
b) Increase the dose for non-pregnant patients
c) Administer with a contraceptive
d) Only administer the medication in the morning

Answer: a) Ensure the patient is not pregnant

Which of the following is an example of a medication given by the intradermal route?

a) Influenza vaccine
b) Insulin
c) Tuberculosis test
d) Vitamin B12 injection

Answer: c) Tuberculosis test

A nurse is administering a medication to a pediatric patient. Which is the correct method for calculating the correct pediatric dosage?

a) Using the patient’s age and weight
b) Using the patient’s height and gender
c) Using the adult dose as a baseline
d) Using the average weight for children of the same age

Answer: a) Using the patient’s age and weight

Which of the following is an appropriate action when a patient is being administered a drug that may cause sedation?

a) Instruct the patient to rest and avoid activities that require concentration
b) Encourage the patient to drink caffeine
c) Instruct the patient to perform light exercises
d) Withhold the medication if the patient complains of drowsiness

Answer: a) Instruct the patient to rest and avoid activities that require concentration

Which of the following is the best method to verify that a medication is correctly administered to the right patient?

a) Ask the patient their name
b) Check the patient’s wristband
c) Ask the family member for confirmation
d) Compare the medication with the patient’s chart

Answer: b) Check the patient’s wristband

Which of the following is an example of a non-parenteral route of medication administration?

a) Intravenous
b) Subcutaneous
c) Oral
d) Intramuscular

Answer: c) Oral

When administering a controlled substance, which is the nurse’s responsibility?

a) Document the patient’s vital signs
b) Double-check the drug with a second nurse
c) Administer the medication at the prescribed time
d) Ensure the patient is comfortable and relaxed

Answer: b) Double-check the drug with a second nurse

What is the most common route of administration for insulin?

a) Oral
b) Subcutaneous
c) Intramuscular
d) Intravenous

Answer: b) Subcutaneous

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