NCLEX Cancer and Oncology Nursing Exam Questions and Answers

181 Questions and Answers

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Caring for individuals with cancer requires specialized nursing knowledge, critical thinking, and compassionate care strategies. This NCLEX Cancer and Oncology Nursing Exam Questions and Answers resource is designed to equip future nurses with the essential skills and clinical understanding needed to provide evidence-based care to oncology patients—an important area assessed on the NCLEX-RN exam.

This practice exam covers a wide spectrum of oncology nursing topics, including cancer pathophysiology, staging and grading of tumors, diagnostic procedures, treatment modalities (such as chemotherapy, radiation, surgery, and immunotherapy), and side effect management. It also emphasizes safe handling of hazardous medications, infection prevention in immunocompromised patients, and effective pain management protocols.

You’ll work through scenario-based questions that simulate real clinical environments—focusing on patient assessment, nursing interventions, and care planning throughout various stages of cancer. Topics such as psychosocial support, end-of-life care, nutritional management, and palliative care are also integrated to support a holistic approach to nursing practice.

The questions also reinforce knowledge about patient education, ethical issues in oncology, survivorship care planning, and the coordination of interdisciplinary care teams. These are crucial concepts for nurses working in both acute and outpatient oncology settings.

Aligned with the latest NCLEX test plan, this resource strengthens your clinical judgment, prioritization, and safety-focused decision-making. It helps you confidently respond to complex situations involving rapidly changing patient conditions and multifaceted care needs.

This exam preparation tool is ideal for nursing students, graduates preparing for the NCLEX, or healthcare professionals looking to deepen their understanding of cancer care. By using this resource, you’ll not only be prepared for exam success but also better equipped to support patients and families navigating the cancer journey.

Sample Questions and Answers

  1. Which of the following is the most common side effect of chemotherapy?
    • A) Diarrhea
    • B) Nausea and vomiting
    • C) Pain
    • D) Anemia
    • Answer: B) Nausea and vomiting
  2. A patient with cancer is receiving radiation therapy. What is the nurse’s priority action?
    • A) Monitor the patient’s vital signs.
    • B) Assess the patient’s skin for radiation burns.
    • C) Ensure the patient is well-hydrated.
    • D) Administer antiemetics as prescribed.
    • Answer: B) Assess the patient’s skin for radiation burns.
  3. A nurse is teaching a patient with cancer about chemotherapy. Which of the following should the nurse include?
    • A) “You will need to avoid all physical activity during treatment.”
    • B) “Chemotherapy can cause hair loss, but it is usually temporary.”
    • C) “Chemotherapy will not affect your ability to work.”
    • D) “You will not need to follow a special diet during treatment.”
    • Answer: B) “Chemotherapy can cause hair loss, but it is usually temporary.”
  4. Which of the following is a common sign of radiation sickness?
    • A) Severe headache
    • B) Abdominal cramping
    • C) Nausea and vomiting
    • D) Sudden weight gain
    • Answer: C) Nausea and vomiting
  5. A patient with cancer has a platelet count of 45,000/mm³. What is the most appropriate nursing intervention?
    • A) Place the patient on strict bed rest.
    • B) Encourage the patient to increase fluid intake.
    • C) Monitor for signs of bleeding.
    • D) Administer blood transfusions.
    • Answer: C) Monitor for signs of bleeding.
  6. A nurse is caring for a patient who is receiving chemotherapy. Which of the following is a priority nursing assessment?
    • A) Respiratory rate
    • B) Bowel function
    • C) Blood pressure
    • D) White blood cell count
    • Answer: D) White blood cell count
  7. Which of the following chemotherapy side effects is associated with an increased risk of infection?
    • A) Alopecia
    • B) Nausea
    • C) Neutropenia
    • D) Fatigue
    • Answer: C) Neutropenia
  8. What is the primary nursing concern for a patient receiving chemotherapy with a low white blood cell count?
    • A) Risk for hemorrhage
    • B) Risk for infection
    • C) Risk for constipation
    • D) Risk for dehydration
    • Answer: B) Risk for infection
  9. A patient with cancer is experiencing pain. The nurse should assess for which of the following?
    • A) Pain scale rating
    • B) Appetite changes
    • C) Bowel movements
    • D) Skin temperature
    • Answer: A) Pain scale rating
  10. A nurse is caring for a patient undergoing chemotherapy. Which of the following is an appropriate nursing intervention to manage nausea?
  • A) Administer antipyretics
  • B) Encourage the patient to eat large meals.
  • C) Offer ginger or peppermint tea.
  • D) Increase the patient’s fluid intake to 3 liters per day.
  • Answer: C) Offer ginger or peppermint tea.
  1. Which of the following findings would indicate a possible complication of a bone marrow suppression due to chemotherapy?
  • A) Elevated white blood cell count
  • B) Sudden weight gain
  • C) Low hemoglobin level
  • D) High platelet count
  • Answer: C) Low hemoglobin level
  1. A patient is receiving external radiation therapy. The nurse should teach the patient to avoid which of the following?
  • A) Exposure to sunlight
  • B) Physical activity
  • C) Taking warm baths
  • D) Drinking cold beverages
  • Answer: A) Exposure to sunlight
  1. Which of the following is an expected side effect of external radiation therapy?
  • A) Hair loss in the treatment area
  • B) Increased appetite
  • C) Weight gain
  • D) Decreased risk of infection
  • Answer: A) Hair loss in the treatment area
  1. Which of the following statements by the patient indicates the need for further teaching regarding chemotherapy side effects?
  • A) “I may experience nausea and vomiting after chemotherapy.”
  • B) “I should avoid people with infections during my treatment.”
  • C) “I will be able to continue working without any changes.”
  • D) “My hair may fall out, but it will grow back after treatment.”
  • Answer: C) “I will be able to continue working without any changes.”
  1. Which of the following is the most common symptom of leukemia?
  • A) Fatigue
  • B) Weight gain
  • C) Night sweats
  • D) Difficulty breathing
  • Answer: A) Fatigue
  1. A nurse is assessing a patient with metastatic cancer. Which of the following findings is most concerning?
  • A) Pain localized to the affected area
  • B) New onset of shortness of breath
  • C) Decreased appetite
  • D) Fatigue
  • Answer: B) New onset of shortness of breath
  1. Which of the following lab results would be most concerning for a patient receiving chemotherapy?
  • A) Hemoglobin 10 g/dL
  • B) Platelet count of 30,000/mm³
  • C) Sodium level 137 mEq/L
  • D) Potassium level 4.0 mEq/L
  • Answer: B) Platelet count of 30,000/mm³
  1. A patient with breast cancer is undergoing chemotherapy. Which of the following interventions should the nurse implement to manage fatigue?
  • A) Encourage the patient to increase physical activity.
  • B) Suggest the patient take afternoon naps.
  • C) Offer frequent small meals to improve energy levels.
  • D) Limit the patient’s fluid intake to reduce fatigue.
  • Answer: B) Suggest the patient take afternoon naps.
  1. A patient with cancer has developed superior vena cava syndrome. Which of the following symptoms is most likely?
  • A) Swelling of the face and neck
  • B) Severe abdominal pain
  • C) Difficulty swallowing
  • D) Diarrhea
  • Answer: A) Swelling of the face and neck
  1. A patient with cancer asks the nurse about ways to cope with anxiety. Which of the following is the most appropriate response?
  • A) “You should try to avoid thinking about your diagnosis.”
  • B) “It’s helpful to talk with other patients who have cancer.”
  • C) “You should avoid any physical activity to prevent stress.”
  • D) “Anxiety is a normal part of treatment and should be ignored.”
  • Answer: B) “It’s helpful to talk with other patients who have cancer.”
  1. Which of the following should be included in a nurse’s assessment of a patient receiving chemotherapy?
  • A) Nutritional status
  • B) Eye color
  • C) Urine output
  • D) Urinary retention
  • Answer: A) Nutritional status
  1. A patient is receiving chemotherapy and develops mucositis. Which of the following interventions is most appropriate?
  • A) Administer pain medication as prescribed.
  • B) Encourage the patient to avoid all oral care.
  • C) Offer hot liquids to soothe the mouth.
  • D) Recommend chewing gum to stimulate saliva production.
  • Answer: A) Administer pain medication as prescribed.
  1. A nurse is caring for a patient with a newly diagnosed cancer. Which of the following is most important to include in the patient’s plan of care?
  • A) Educating the patient about the prognosis
  • B) Assessing the patient’s coping strategies
  • C) Reassuring the patient that treatment will be effective
  • D) Encouraging the patient to avoid all social interactions
  • Answer: B) Assessing the patient’s coping strategies
  1. Which of the following medications is commonly used to treat chemotherapy-induced nausea and vomiting?
  • A) Ondansetron
  • B) Dantrolene
  • C) Prednisone
  • D) Lorazepam
  • Answer: A) Ondansetron
  1. A patient undergoing radiation therapy reports feeling tired and fatigued. Which of the following interventions is most appropriate?
  • A) Encourage the patient to take regular naps.
  • B) Increase the patient’s physical activity level.
  • C) Discourage the patient from resting.
  • D) Restrict the patient’s intake of fluids.
  • Answer: A) Encourage the patient to take regular naps.
  1. A nurse is caring for a patient receiving chemotherapy. Which of the following would be most concerning?
  • A) Complaints of mild nausea
  • B) WBC count of 3,000/mm³
  • C) Diarrhea
  • D) Mild hair loss
  • Answer: B) WBC count of 3,000/mm³
  1. A nurse is providing care for a patient with cancer experiencing severe pain. Which of the following is a priority?
  • A) Administer prescribed analgesics as needed.
  • B) Encourage the patient to engage in physical therapy.
  • C) Discuss alternative therapies before providing medications.
  • D) Offer spiritual counseling to address emotional distress.
  • Answer: A) Administer prescribed analgesics as needed.
  1. Which of the following is the most appropriate action for a nurse caring for a patient with terminal cancer?
  • A) Focus solely on the patient’s physical symptoms.
  • B) Emphasize curative treatments over palliative care.
  • C) Provide comfort measures to alleviate suffering.
  • D) Avoid discussions about end-of-life care.
  • Answer: C) Provide comfort measures to alleviate suffering.
  1. A nurse is caring for a patient with lung cancer who is receiving palliative care. Which of the following interventions should the nurse implement to address pain management?
  • A) Administer opioid analgesics regularly as prescribed.
  • B) Offer herbal supplements to reduce discomfort.
  • C) Encourage the patient to endure the pain.
  • D) Limit fluid intake to reduce discomfort.
  • Answer: A) Administer opioid analgesics regularly as prescribed.
  1. Which of the following is an early warning sign of cancer?
  • A) Unexplained weight loss
  • B) Fever and chills
  • C) Leg swelling
  • D) Loss of appetite
  • Answer: A) Unexplained weight loss

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