Anatomy & Physiology Endocrine System Practice Questions and Answers

180 Questions and Answers

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Prepare to master one of the most vital systems of the human body with our Anatomy & Physiology Endocrine System Practice Questions and Answers. This carefully crafted practice exam is designed for nursing students, pre-med learners, and anyone looking to strengthen their understanding of endocrine system structure and function.

The endocrine system plays a critical role in regulating hormones, metabolism, growth, stress responses, and more. This quiz delivers a deep dive into all essential topics, including:

  • Major endocrine glands: pituitary, thyroid, adrenal, pancreas, pineal, ovaries, testes

  • Hormones and their physiological effects

  • Feedback mechanisms (positive and negative feedback loops)

  • Disorders such as hypothyroidism, hyperthyroidism, diabetes mellitus, Cushing’s syndrome

  • Hormonal regulation of homeostasis

  • Interactions between endocrine and nervous systems

  • Endocrine signaling vs. nervous signaling

  • Hormone secretion pathways and target organ responses

  • Mechanisms of steroid and peptide hormone action

  • Comprehensive explanations for every answer to enhance learning retention

Each question in this practice test has been thoughtfully created to reflect real exam scenarios, helping you gain confidence and reinforce core concepts. Whether you’re studying for the NCLEX, TEAS, HESI, or a university-level anatomy and physiology course, these Anatomy & Physiology Endocrine System Practice Questions and Answers are your go-to resource.

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Sample Questions and Answers

Which of the following glands produces insulin?

A) Thyroid
B) Pancreas
C) Pituitary
D) Adrenal
Answer: B) Pancreas

What is the primary function of the hypothalamus in the endocrine system?

A) Regulate metabolism
B) Secrete hormones that regulate the pituitary gland
C) Control blood sugar levels
D) Control body temperature
Answer: B) Secrete hormones that regulate the pituitary gland

Which hormone is primarily responsible for regulating metabolism?

A) Insulin
B) Thyroxine (T4)
C) Cortisol
D) Prolactin
Answer: B) Thyroxine (T4)

Which hormone is released by the adrenal glands in response to stress?

A) Estrogen
B) Testosterone
C) Cortisol
D) Oxytocin
Answer: C) Cortisol

Which of the following is a function of antidiuretic hormone (ADH)?

A) Stimulates milk production
B) Increases water reabsorption in the kidneys
C) Stimulates uterine contractions
D) Increases blood glucose levels
Answer: B) Increases water reabsorption in the kidneys

What is the role of parathyroid hormone (PTH)?

A) Regulate calcium levels in the blood
B) Stimulate milk production
C) Increase glucose uptake by cells
D) Regulate the menstrual cycle
Answer: A) Regulate calcium levels in the blood

Which hormone is produced by the pineal gland?

A) Melatonin
B) Estrogen
C) Progesterone
D) Cortisol
Answer: A) Melatonin

Which of the following glands secretes adrenaline (epinephrine)?

A) Pineal gland
B) Pituitary gland
C) Adrenal glands
D) Thyroid gland
Answer: C) Adrenal glands

The hormone aldosterone helps to regulate which of the following?

A) Blood glucose levels
B) Blood pressure
C) Milk production
D) Immune function
Answer: B) Blood pressure

Which gland produces growth hormone (GH)?

A) Pineal gland
B) Adrenal glands
C) Pituitary gland
D) Thyroid gland
Answer: C) Pituitary gland

What is the primary effect of insulin?

A) Stimulate red blood cell production
B) Lower blood glucose levels
C) Increase blood calcium levels
D) Stimulate digestion
Answer: B) Lower blood glucose levels

Which of the following is a function of the thyroid gland?

A) Regulation of water balance
B) Regulation of metabolism
C) Regulation of calcium balance
D) Production of cortisol
Answer: B) Regulation of metabolism

Which hormone does the adrenal medulla secrete?

A) Insulin
B) Cortisol
C) Epinephrine
D) Thyroxine
Answer: C) Epinephrine

The function of the hormone oxytocin is primarily to:

A) Stimulate uterine contractions during labor
B) Regulate calcium homeostasis
C) Promote glucose uptake
D) Control body temperature
Answer: A) Stimulate uterine contractions during labor

Which of the following is produced by the beta cells of the pancreas?

A) Insulin
B) Glucagon
C) Cortisol
D) Somatostatin
Answer: A) Insulin

Which of the following is released by the anterior pituitary gland?

A) Oxytocin
B) Prolactin
C) Antidiuretic hormone
D) Melatonin
Answer: B) Prolactin

Which hormone is responsible for the fight-or-flight response?

A) Insulin
B) Epinephrine
C) Thyroxine
D) Estrogen
Answer: B) Epinephrine

Which gland is known as the “master gland” of the endocrine system?

A) Pineal gland
B) Thyroid gland
C) Pituitary gland
D) Parathyroid gland
Answer: C) Pituitary gland

What is the main function of thyroid-stimulating hormone (TSH)?

A) Stimulate the release of thyroid hormones
B) Increase blood calcium levels
C) Stimulate milk production
D) Promote growth in children
Answer: A) Stimulate the release of thyroid hormones

Which of the following is NOT a function of cortisol?

A) Promote gluconeogenesis
B) Reduce inflammation
C) Regulate blood pressure
D) Stimulate the production of red blood cells
Answer: D) Stimulate the production of red blood cells

Which of the following hormones is involved in regulating the menstrual cycle?

A) Prolactin
B) Estrogen
C) Thyroxine
D) Growth hormone
Answer: B) Estrogen

Which organ is responsible for the secretion of glucagon?

A) Kidneys
B) Liver
C) Pancreas
D) Adrenal glands
Answer: C) Pancreas

What is the effect of thyroid hormones (T3 and T4)?

A) Increase heart rate
B) Decrease metabolic rate
C) Promote digestion
D) Regulate calcium levels
Answer: A) Increase heart rate

Which of the following is a function of prolactin?

A) Stimulate milk production
B) Regulate calcium metabolism
C) Increase water retention
D) Regulate stress response
Answer: A) Stimulate milk production

Which of the following hormones regulates sodium and potassium balance?

A) Insulin
B) Aldosterone
C) Progesterone
D) Parathyroid hormone
Answer: B) Aldosterone

Which hormone stimulates the release of eggs from the ovaries?

A) Luteinizing hormone (LH)
B) Estrogen
C) Prolactin
D) Oxytocin
Answer: A) Luteinizing hormone (LH)

What is the role of thymosin?

A) Stimulate the production of red blood cells
B) Regulate the immune system
C) Control metabolism
D) Promote bone growth
Answer: B) Regulate the immune system

Which of the following hormones is primarily involved in the regulation of blood calcium levels?

A) Thyroxine
B) Parathyroid hormone
C) Growth hormone
D) Insulin
Answer: B) Parathyroid hormone

What is the main function of the hormone leptin?

A) Control appetite and energy balance
B) Regulate blood glucose levels
C) Stimulate uterine contractions
D) Control circadian rhythms
Answer: A) Control appetite and energy balance

What type of hormone is aldosterone?

A) Glucocorticoid
B) Mineralocorticoid
C) Catecholamine
D) Androgen
Answer: B) Mineralocorticoid

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