NCLEX Hematologic Disorders and Anemia Exam Questions and Answers

160 Questions and Answers

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Master the complexities of blood disorders with this focused NCLEX Hematologic Disorders and Anemia Exam Questions and Answers resource. Specifically crafted for nursing students preparing for the NCLEX, this practice test covers a wide range of high-yield hematologic topics and clinical scenarios.

Key topics included:

  • Types of anemia: iron-deficiency, aplastic, hemolytic, pernicious, and sickle cell anemia

  • Blood clotting disorders such as hemophilia and thrombocytopenia

  • Diagnostic tests: CBC, reticulocyte count, iron studies, bone marrow biopsy

  • Blood transfusion procedures and nursing responsibilities

  • Pharmacologic management: iron supplements, vitamin B12, folic acid, and erythropoiesis-stimulating agents

  • Immune system involvement in hematologic diseases

  • Complications such as bleeding, fatigue, infection risk, and hypoxia

  • Evidence-based nursing care plans and patient teaching

  • NCLEX-style questions with rationales for every correct and incorrect answer

Each question is designed to reflect real NCLEX exam structure, improving your critical thinking, clinical judgment, and test-taking skills.

Sample Questions and Answers

  1. Which of the following is a common symptom of iron-deficiency anemia?
  • a) Increased energy levels
  • b) Pallor
  • c) Jaundice
  • d) Cyanosis
    Answer: b) Pallor
  1. What is the primary treatment for sickle cell anemia during a crisis?
  • a) Blood transfusions
  • b) Pain management
  • c) Vitamin B12 injections
  • d) Antihistamines
    Answer: b) Pain management
  1. Which lab result would most likely be elevated in a patient with pernicious anemia?
  • a) Hemoglobin
  • b) MCV (Mean Corpuscular Volume)
  • c) Platelets
  • d) White blood cells
    Answer: b) MCV (Mean Corpuscular Volume)
  1. What is the hallmark sign of hemolytic anemia?
  • a) Hypotension
  • b) Jaundice
  • c) Tachycardia
  • d) Increased platelet count
    Answer: b) Jaundice
  1. A patient with iron-deficiency anemia is prescribed ferrous sulfate. Which of the following should the nurse include in the teaching plan?
  • a) “Take the medication with milk to increase absorption.”
  • b) “You may notice a change in the color of your stools.”
  • c) “Avoid taking the medication on an empty stomach.”
  • d) “Limit fluids while taking this medication.”
    Answer: b) “You may notice a change in the color of your stools.”
  1. Which of the following is a classic sign of anemia?
  • a) Chest pain
  • b) Hypoxia
  • c) Fatigue
  • d) Shortness of breath
    Answer: c) Fatigue
  1. In which type of anemia is a decrease in intrinsic factor production seen?
  • a) Iron-deficiency anemia
  • b) Aplastic anemia
  • c) Pernicious anemia
  • d) Sickle cell anemia
    Answer: c) Pernicious anemia
  1. A nurse is caring for a client with anemia. What is the priority nursing intervention?
  • a) Encourage frequent rest periods
  • b) Monitor for signs of bleeding
  • c) Administer iron supplements
  • d) Educate the patient about the condition
    Answer: a) Encourage frequent rest periods
  1. What is the most appropriate nursing action when a patient is receiving a blood transfusion and experiences chills and fever?
  • a) Continue the transfusion and monitor closely
  • b) Stop the transfusion and notify the healthcare provider
  • c) Give an antihistamine and continue the transfusion
  • d) Administer oxygen and continue the transfusion
    Answer: b) Stop the transfusion and notify the healthcare provider
  1. A patient with anemia is prescribed epoetin alfa. What is the nurse’s primary concern when administering this medication?
  • a) Risk for thrombosis
  • b) Risk for infection
  • c) Risk for hypokalemia
  • d) Risk for nausea and vomiting
    Answer: a) Risk for thrombosis
  1. A nurse is caring for a patient with hemophilia. What is the priority nursing diagnosis for this patient?
  • a) Risk for injury
  • b) Ineffective airway clearance
  • c) Impaired skin integrity
  • d) Fluid volume excess
    Answer: a) Risk for injury
  1. Which of the following is most likely to cause aplastic anemia?
  • a) Excessive iron intake
  • b) Viral infections
  • c) Severe blood loss
  • d) Excessive exercise
    Answer: b) Viral infections
  1. Which diagnostic test is used to confirm the diagnosis of sickle cell anemia?
  • a) Bone marrow biopsy
  • b) Hemoglobin electrophoresis
  • c) Complete blood count (CBC)
  • d) Coagulation profile
    Answer: b) Hemoglobin electrophoresis
  1. What is the primary goal for the patient with thalassemia major?
  • a) Prevent bleeding
  • b) Manage pain
  • c) Prevent iron overload
  • d) Increase white blood cell count
    Answer: c) Prevent iron overload
  1. A patient with anemia presents with weakness and dizziness. What is the most likely cause?
  • a) Decreased oxygen-carrying capacity
  • b) Increased red blood cell production
  • c) Hyperkalemia
  • d) Infection
    Answer: a) Decreased oxygen-carrying capacity
  1. Which condition is associated with a decreased reticulocyte count?
  • a) Iron-deficiency anemia
  • b) Aplastic anemia
  • c) Hemorrhagic anemia
  • d) Sickle cell anemia
    Answer: b) Aplastic anemia
  1. The nurse is caring for a patient with a hemoglobin level of 7 g/dL. What should the nurse be most concerned about?
  • a) Risk for fatigue
  • b) Risk for infection
  • c) Risk for hemorrhage
  • d) Risk for hypertension
    Answer: a) Risk for fatigue
  1. What is the primary characteristic of anemia caused by blood loss?
  • a) Decreased erythropoiesis
  • b) Hemolysis
  • c) Hypovolemia
  • d) Bone marrow suppression
    Answer: c) Hypovolemia
  1. Which of the following is a common complication of untreated pernicious anemia?
  • a) Cardiac arrhythmias
  • b) Neurological damage
  • c) Kidney failure
  • d) Respiratory distress
    Answer: b) Neurological damage
  1. A patient with sickle cell anemia is hospitalized for pain management. Which of the following is the most appropriate intervention?
  • a) Administering oxygen
  • b) Providing a high-calorie diet
  • c) Encouraging fluid intake
  • d) Administering analgesics
    Answer: d) Administering analgesics
  1. What is a major complication of chronic blood transfusions in patients with thalassemia?
  • a) Hyperglycemia
  • b) Iron overload
  • c) Pulmonary embolism
  • d) Hypertension
    Answer: b) Iron overload
  1. A nurse is teaching a patient about foods rich in folic acid. Which of the following foods should the nurse recommend?
  • a) Oranges
  • b) Whole grains
  • c) Green leafy vegetables
  • d) Red meats
    Answer: c) Green leafy vegetables
  1. In a patient with polycythemia vera, what lab result would the nurse expect to find?
  • a) Decreased hematocrit
  • b) Elevated white blood cell count
  • c) Elevated red blood cell mass
  • d) Decreased platelet count
    Answer: c) Elevated red blood cell mass
  1. What should the nurse monitor for in a patient receiving chemotherapy who has a low white blood cell count?
  • a) Increased risk of infection
  • b) Increased risk of bleeding
  • c) Increased risk of fluid volume overload
  • d) Increased risk of arrhythmias
    Answer: a) Increased risk of infection
  1. What is the main purpose of administering iron supplements to a patient with iron-deficiency anemia?
  • a) To increase hemoglobin production
  • b) To increase red blood cell destruction
  • c) To reduce blood viscosity
  • d) To increase platelet aggregation
    Answer: a) To increase hemoglobin production
  1. A nurse is preparing a patient for a bone marrow biopsy. What is the priority nursing intervention?
  • a) Administer pain medication as prescribed
  • b) Provide the patient with a sedative
  • c) Ensure the patient has a full stomach
  • d) Instruct the patient to avoid fluid intake
    Answer: a) Administer pain medication as prescribed
  1. A nurse is caring for a patient who is receiving a blood transfusion. The patient begins to experience hives, itching, and difficulty breathing. What is the nurse’s priority action?
  • a) Stop the transfusion and administer epinephrine
  • b) Continue the transfusion and monitor vital signs
  • c) Administer antihistamines and continue the transfusion
  • d) Administer oxygen and notify the physician
    Answer: a) Stop the transfusion and administer epinephrine
  1. Which of the following is the most common cause of acquired anemia?
  • a) Blood loss
  • b) Vitamin B12 deficiency
  • c) Hemolysis
  • d) Genetic mutation
    Answer: a) Blood loss
  1. What is the primary goal in treating a patient with sickle cell anemia?
  • a) Prevent infection
  • b) Maintain adequate oxygenation
  • c) Increase iron levels
  • d) Reduce red blood cell production
    Answer: b) Maintain adequate oxygenation
  1. Which of the following medications is most commonly prescribed to treat pernicious anemia?
  • a) Vitamin B12 injections
  • b) Folic acid supplements
  • c) Iron supplements
  • d) Erythropoietin
    Answer: a) Vitamin B12 injections

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