Endocrine & Metabolic Drugs Exam Practice Questions and Answers

175 Questions and Answers

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A solid command of endocrine and metabolic pharmacology is essential for safe clinical decision-making and success in healthcare exams. This Endocrine & Metabolic Drugs Exam Practice Questions and Answers quiz is designed to help you master the medications used in managing hormonal and metabolic disorders. Ideal for nursing, pharmacy, and medical students, this resource offers focused, exam-style questions that reflect real-world clinical scenarios.

The quiz provides comprehensive coverage of drug therapies for conditions such as diabetes mellitus, thyroid disorders, adrenal insufficiency, pituitary dysfunction, metabolic syndrome, and osteoporosis. You’ll explore essential drug classes including insulin types, oral hypoglycemics, thyroid hormones, antithyroid agents, corticosteroids, growth hormone modulators, bisphosphonates, and hormone replacement therapies.

Each question is developed to test your understanding of mechanisms of action, indications, side effects, contraindications, drug interactions, and administration techniques. Additional emphasis is placed on nursing interventions, patient education, blood glucose monitoring, hormone level tracking, and dosage adjustments, particularly in pediatric, geriatric, and chronically ill populations.

Structured to mirror the format of high-stakes exams such as NCLEX, HESI, ATI, and in-course pharmacology assessments, this practice tool enhances your test-taking confidence and improves retention of critical concepts. Scenario-based questions encourage clinical reasoning and help solidify your knowledge for both theoretical exams and practical applications.

Whether you’re reviewing for a final exam, prepping for licensing, or simply reinforcing your understanding of endocrine and metabolic pharmacology, this resource delivers a reliable and effective study experience. The Endocrine & Metabolic Drugs Exam Practice Questions and Answers are crafted to meet academic standards and support long-term success in healthcare education and clinical practice.

Sample Questions and Answers

  1. Which of the following is a common side effect of levothyroxine (Synthroid)?
    • a) Hyperglycemia
    • b) Hypokalemia
    • c) Weight gain
    • d) Tachycardia
    • Answer: d) Tachycardia
  2. Which of the following is the primary use for metformin?
    • a) Type 1 diabetes
    • b) Type 2 diabetes
    • c) Hyperthyroidism
    • d) Osteoporosis
    • Answer: b) Type 2 diabetes
  3. What is the mechanism of action of insulin?
    • a) Increases hepatic glucose production
    • b) Promotes glucose uptake by cells
    • c) Increases insulin resistance
    • d) Decreases lipolysis
    • Answer: b) Promotes glucose uptake by cells
  4. Which class of drugs is used to treat hypothyroidism?
    • a) Beta-blockers
    • b) Thionamides
    • c) Thyroid hormones
    • d) Antidiuretics
    • Answer: c) Thyroid hormones
  5. Which of the following is a potential adverse effect of corticosteroid therapy?
    • a) Hyperkalemia
    • b) Hyperglycemia
    • c) Hypotension
    • d) Hypothyroidism
    • Answer: b) Hyperglycemia
  6. Which medication is commonly prescribed to treat hyperaldosteronism?
    • a) Spironolactone
    • b) Methimazole
    • c) Insulin
    • d) Prednisone
    • Answer: a) Spironolactone
  7. The main action of GLP-1 receptor agonists in diabetes is to:
    • a) Increase insulin sensitivity
    • b) Increase insulin secretion
    • c) Increase glucagon release
    • d) Decrease appetite
    • Answer: b) Increase insulin secretion
  8. Which of the following medications is a short-acting insulin?
    • a) Insulin glargine
    • b) Insulin aspart
    • c) Insulin detemir
    • d) Insulin glulisine
    • Answer: b) Insulin aspart
  9. Which medication is used to treat osteoporosis by inhibiting osteoclast activity?
    • a) Calcitonin
    • b) Raloxifene
    • c) Alendronate
    • d) Teriparatide
    • Answer: c) Alendronate
  10. What is the most serious potential side effect of thiazolidinediones (TZDs)?
  • a) Liver toxicity
  • b) Weight loss
  • c) Bone fractures
  • d) Heart failure
  • Answer: d) Heart failure
  1. Which of the following is a characteristic of levothyroxine overdose?
  • a) Bradycardia
  • b) Hypotension
  • c) Heat intolerance
  • d) Cold intolerance
  • Answer: c) Heat intolerance
  1. Which of the following is used as adjunct therapy for hyperglycemia in type 2 diabetes?
  • a) Insulin glargine
  • b) Metformin
  • c) Glucagon
  • d) Propylthiouracil
  • Answer: b) Metformin
  1. What is the mechanism of action of sulfonylureas?
  • a) Increase insulin secretion
  • b) Decrease insulin secretion
  • c) Increase glucose uptake by cells
  • d) Inhibit hepatic glucose production
  • Answer: a) Increase insulin secretion
  1. Which of the following medications is used to treat acromegaly?
  • a) Cabergoline
  • b) Desmopressin
  • c) Octreotide
  • d) Hydrocortisone
  • Answer: c) Octreotide
  1. What class of drugs is typically used to manage Cushing’s syndrome?
  • a) Thiazides
  • b) Corticosteroids
  • c) Antifungals
  • d) Cortisol inhibitors
  • Answer: d) Cortisol inhibitors
  1. What is the primary use of bisphosphonates?
  • a) Hypercalcemia
  • b) Osteoporosis
  • c) Hyperparathyroidism
  • d) Hypothyroidism
  • Answer: b) Osteoporosis
  1. Which of the following medications can cause a significant drop in blood glucose levels?
  • a) Prednisone
  • b) Metformin
  • c) Glipizide
  • d) Levothyroxine
  • Answer: c) Glipizide
  1. Which of the following is a side effect of long-term corticosteroid use?
  • a) Decreased blood glucose
  • b) Weight loss
  • c) Adrenal suppression
  • d) Reduced blood pressure
  • Answer: c) Adrenal suppression
  1. Which class of drugs is used to treat hyperglycemia in type 1 diabetes?
  • a) Insulin
  • b) Biguanides
  • c) GLP-1 receptor agonists
  • d) Thiazolidinediones
  • Answer: a) Insulin
  1. What is the main purpose of the drug desmopressin?
  • a) Treat diabetes insipidus
  • b) Treat hypothyroidism
  • c) Lower blood pressure
  • d) Increase blood glucose
  • Answer: a) Treat diabetes insipidus
  1. Which drug is used to treat hyperparathyroidism?
  • a) Calcitriol
  • b) Methimazole
  • c) Cinacalcet
  • d) Propylthiouracil
  • Answer: c) Cinacalcet
  1. Which of the following drugs should be taken on an empty stomach to maximize absorption?
  • a) Levothyroxine
  • b) Metformin
  • c) Prednisone
  • d) Glimepiride
  • Answer: a) Levothyroxine
  1. Which of the following can be a side effect of propylthiouracil (PTU) used for hyperthyroidism?
  • a) Hepatotoxicity
  • b) Hypokalemia
  • c) Weight gain
  • d) Hyperkalemia
  • Answer: a) Hepatotoxicity
  1. Which hormone therapy is commonly used in women after menopause to prevent osteoporosis?
  • a) Thyroid hormone
  • b) Estrogen
  • c) Growth hormone
  • d) Insulin
  • Answer: b) Estrogen
  1. Which of the following medications is used to manage diabetic ketoacidosis (DKA)?
  • a) Insulin
  • b) Glucagon
  • c) Metformin
  • d) Levothyroxine
  • Answer: a) Insulin
  1. Which of the following is a serious side effect of using oral contraceptives in women with a history of diabetes?
  • a) Hypoglycemia
  • b) Hyperglycemia
  • c) Hypotension
  • d) Hypertension
  • Answer: b) Hyperglycemia
  1. Which drug class can be used to reduce serum potassium levels in hyperkalemia?
  • a) Potassium-sparing diuretics
  • b) Corticosteroids
  • c) Sodium bicarbonate
  • d) Insulin
  • Answer: d) Insulin
  1. Which of the following drugs can cause hypothyroidism?
  • a) Levothyroxine
  • b) Amiodarone
  • c) Metformin
  • d) Spironolactone
  • Answer: b) Amiodarone
  1. What is the main action of thionamides like methimazole?
  • a) Increase thyroid hormone production
  • b) Inhibit thyroid hormone production
  • c) Stimulate thyroid-stimulating hormone release
  • d) Block thyroid hormone receptors
  • Answer: b) Inhibit thyroid hormone production
  1. Which medication is used to treat the metabolic effects of Cushing’s syndrome?
  • a) Mifepristone
  • b) Desmopressin
  • c) Prednisone
  • d) Glucagon
  • Answer: a) Mifepristone

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