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Anti-inflammatory Drugs Exam Practice Questions and Answers

150 Questions and Answers

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A solid grasp of anti-inflammatory pharmacology is essential for healthcare students and professionals managing conditions involving pain, inflammation, and immune response. This Anti-inflammatory Drugs Practice Exam Quiz is specifically designed to help you understand the medications commonly used to treat inflammatory disorders and sharpen your readiness for clinical exams and real-world application.

The quiz covers a wide range of anti-inflammatory agents, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, COX-2 inhibitors, disease-modifying antirheumatic drugs (DMARDs), and biologic agents. It addresses both acute and chronic conditions such as arthritis, autoimmune diseases, musculoskeletal injuries, and post-operative inflammation.

Each question is built around clinical scenarios that test your knowledge of mechanisms of action, therapeutic uses, adverse effects, contraindications, drug interactions, and patient safety protocols. Special emphasis is placed on nursing care considerations, including monitoring for gastrointestinal bleeding, renal function, fluid retention, blood pressure changes, and the safe tapering of steroid therapies.

Ideal for students preparing for exams like the NCLEX-RN, HESI, ATI, or pharmacology course assessments, this quiz mirrors real exam formatting to enhance critical thinking, application skills, and test-taking confidence. It also reinforces concepts such as dosing strategies, anti-inflammatory therapy in special populations, immunosuppressive effects, and patient teaching for long-term medication use.

This resource is suitable for nursing, pharmacy, and medical students—as well as allied health professionals—looking to build a strong foundation in anti-inflammatory medication management. It helps learners identify areas for improvement while reinforcing key pharmacological principles and clinical practices.

Carefully aligned with current guidelines and educational standards, the Anti-inflammatory Drugs Practice Exam Quiz is an effective and practical tool for mastering one of the most commonly used classes of drugs in clinical care.

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Sample Questions and Answers

  1. Which of the following is a non-selective NSAID?
    Celecoxib
    B. Aspirin
    C. Acetaminophen
    D. Methotrexate
    Answer: B
  2. What is the primary mechanism of action of NSAIDs?
    Inhibition of cyclooxygenase (COX) enzymes
    B. Blockage of histamine receptors
    C. Activation of serotonin receptors
    D. Stimulation of opioid receptors
    Answer: A
  3. Which of the following is a selective COX-2 inhibitor?
    Naproxen
    B. Diclofenac
    C. Celecoxib
    D. Ibuprofen
    Answer: C
  4. Which NSAID is most associated with Reye’s syndrome in children?
    Ibuprofen
    B. Aspirin
    C. Meloxicam
    D. Celecoxib
    Answer: B
  5. What is the primary adverse effect of NSAIDs on the gastrointestinal tract?
    Diarrhea
    B. Ulceration and bleeding
    C. Constipation
    D. Malabsorption
    Answer: B
  6. What is the role of prostaglandins inhibited by NSAIDs?
    Promote platelet aggregation
    B. Protect gastric mucosa
    C. Reduce blood pressure
    D. Stimulate histamine release
    Answer: B
  7. Which anti-inflammatory drug is commonly used for acute gout attacks?
    Allopurinol
    B. Colchicine
    C. Celecoxib
    D. Methotrexate
    Answer: B
  8. Which of the following NSAIDs has the longest half-life?
    Ibuprofen
    B. Naproxen
    C. Piroxicam
    D. Diclofenac
    Answer: C
  9. Which drug can counteract the platelet inhibition caused by aspirin?
    Warfarin
    B. Acetaminophen
    C. Ibuprofen
    D. Clopidogrel
    Answer: C
  10. Which enzyme is inhibited by glucocorticoids to reduce inflammation?
    COX-1
    B. Phospholipase A2
    C. COX-2
    D. Lipoxygenase
    Answer: B
  11. Which of the following is a non-NSAID anti-inflammatory drug?
    Methotrexate
    B. Ibuprofen
    C. Indomethacin
    D. Naproxen
    Answer: A
  12. Which anti-inflammatory drug is used topically to treat arthritis?
    Celecoxib
    B. Diclofenac
    C. Acetaminophen
    D. Prednisolone
    Answer: B
  13. What is a common side effect of long-term corticosteroid therapy?
    Hyperkalemia
    B. Osteoporosis
    C. Hyperpigmentation
    D. Low blood glucose
    Answer: B
  14. Which anti-inflammatory drug is contraindicated in pregnancy?
    Acetaminophen
    B. Celecoxib
    C. Aspirin
    D. Ibuprofen
    Answer: C
  15. What is the function of leukotriene inhibitors in inflammation?
    Inhibit prostaglandin synthesis
    B. Block leukotriene receptors
    C. Stimulate COX-1 activity
    D. Enhance histamine release
    Answer: B
  16. Which drug is most effective in treating rheumatoid arthritis?
    Ibuprofen
    B. Methotrexate
    C. Aspirin
    D. Acetaminophen
    Answer: B
  17. Which NSAID has the lowest risk of cardiovascular side effects?
    Ibuprofen
    B. Naproxen
    C. Diclofenac
    D. Celecoxib
    Answer: B
  18. Which is a primary adverse effect of glucocorticoids?
    Hypoglycemia
    B. Immunosuppression
    C. Thrombocytopenia
    D. Hyponatremia
    Answer: B
  19. Which COX enzyme is responsible for producing prostaglandins in the stomach lining?
    COX-1
    B. COX-2
    C. COX-3
    D. Both COX-1 and COX-2
    Answer: A
  20. What is the drug of choice for treating aspirin overdose?
    Activated charcoal
    B. N-acetylcysteine
    C. Sodium bicarbonate
    D. Atropine
    Answer: C
  21. Which NSAID is available in injectable form for severe pain?
    Aspirin
    B. Ketorolac
    C. Ibuprofen
    D. Acetaminophen
    Answer: B
  22. Which anti-inflammatory drug is used to prevent migraines?
    Ibuprofen
    B. Topiramate
    C. Aspirin
    D. Celecoxib
    Answer: B
  23. What is the maximum daily dose of acetaminophen for adults to avoid liver toxicity?
    2 grams
    B. 3 grams
    C. 4 grams
    D. 5 grams
    Answer: C
  24. Which NSAID is recommended for patients with cardiovascular risk?
    Aspirin
    B. Ibuprofen
    C. Celecoxib
    D. Diclofenac
    Answer: A
  25. Which NSAID is commonly used in pediatric fever management?
    Aspirin
    B. Ibuprofen
    C. Diclofenac
    D. Naproxen
    Answer: B
  26. Which enzyme does acetaminophen primarily target?
    COX-1
    B. COX-2
    C. COX-3
    D. Lipoxygenase
    Answer: C
  27. Which NSAID is commonly used in sports injuries for reducing inflammation?
    Aspirin
    B. Diclofenac
    C. Celecoxib
    D. Methotrexate
    Answer: B
  28. Which drug can cause Stevens-Johnson syndrome as a rare side effect?
    Naproxen
    B. Aspirin
    C. Ibuprofen
    D. Celecoxib
    Answer: D
  29. Which NSAID is considered safest for patients with a history of peptic ulcers?
    Aspirin
    B. Celecoxib
    C. Naproxen
    D. Ibuprofen
    Answer: B
  30. Which anti-inflammatory drug works by binding to tumor necrosis factor (TNF)?
    Methotrexate
    B. Infliximab
    C. Aspirin
    D. Acetaminophen
    Answer: B

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