Anti-infective Drugs Practice Exam Questions and Answers

180 Questions and Answers

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A deep understanding of anti-infective pharmacology is essential for all healthcare professionals, especially those preparing for clinical exams and licensure. This Anti-infective Drugs Practice Exam Questions and Answers quiz is expertly designed to help nursing, pharmacy, and medical students master the medications used to combat bacterial, viral, fungal, and parasitic infections.

The practice exam covers a wide range of drug classes, including antibiotics, antivirals, antifungals, antiprotozoals, and antiparasitics. Key topics include mechanisms of action, therapeutic indications, spectrum of activity, resistance patterns, adverse effects, and drug interactions. Special attention is given to high-alert medications, commonly prescribed antimicrobials, and infection-specific treatment protocols.

You’ll be tested on critical nursing and clinical responsibilities such as monitoring for superinfections, evaluating therapeutic effectiveness, patient education, proper dosage calculations, and safe administration routes. Questions also reinforce understanding of culture and sensitivity testing, infection control practices, and adverse reactions like nephrotoxicity, hepatotoxicity, hypersensitivity, and antibiotic-associated diarrhea.

Each question is scenario-based, mirroring real clinical situations and the format of exams like the NCLEX, HESI, ATI, and pharmacology course assessments. This structure encourages higher-level critical thinking and prepares students for both academic and real-world application.

This resource is ideal for learners preparing for midterms, finals, or licensure exams in nursing, medicine, or pharmacy. It also serves as an excellent refresher for healthcare providers looking to stay up to date with current anti-infective therapies. The Anti-infective Drugs Practice Exam Questions and Answers quiz helps identify knowledge gaps while reinforcing essential principles of antimicrobial pharmacology.

With its exam-focused structure, clinically relevant content, and alignment with current guidelines, this practice quiz is a valuable tool for building confidence, improving retention, and enhancing overall exam performance in infectious disease pharmacology.


Sample Questions and Answers

Which class of antibiotics inhibits bacterial cell wall synthesis?

  • A) Tetracyclines
  • B) Penicillins
  • C) Macrolides
  • D) Fluoroquinolones
  • Answer: B) Penicillins
  1. What is the mechanism of action of sulfonamides?
  • A) Inhibit bacterial protein synthesis
  • B) Inhibit bacterial DNA replication
  • C) Inhibit folic acid synthesis
  • D) Disrupt cell membrane integrity
  • Answer: C) Inhibit folic acid synthesis
  1. Which of the following is used to treat tuberculosis (TB)?
  • A) Doxycycline
  • B) Isoniazid
  • C) Ciprofloxacin
  • D) Rifampin
  • Answer: B) Isoniazid
  1. Which antibiotic is contraindicated in pregnant women due to its potential to cause bone and teeth abnormalities in the fetus?
  • A) Amoxicillin
  • B) Tetracycline
  • C) Clindamycin
  • D) Cephalexin
  • Answer: B) Tetracycline
  1. Which drug is the treatment of choice for acute urinary tract infections (UTIs)?
  • A) Azithromycin
  • B) Amoxicillin
  • C) Ciprofloxacin
  • D) Nitrofurantoin
  • Answer: D) Nitrofurantoin
  1. Which of the following drugs is a common side effect of nephrotoxicity?
  • A) Vancomycin
  • B) Erythromycin
  • C) Metronidazole
  • D) Amoxicillin
  • Answer: A) Vancomycin
  1. Which of the following antibiotics is a macrolide?
  • A) Erythromycin
  • B) Penicillin
  • C) Ciprofloxacin
  • D) Tetracycline
  • Answer: A) Erythromycin
  1. What is the main mechanism of action of fluoroquinolones?
  • A) Inhibit bacterial cell wall synthesis
  • B) Inhibit protein synthesis
  • C) Inhibit DNA replication
  • D) Inhibit folic acid synthesis
  • Answer: C) Inhibit DNA replication
  1. Which of the following antibiotics is considered broad-spectrum?
  • A) Penicillin
  • B) Tetracycline
  • C) Vancomycin
  • D) Rifampin
  • Answer: B) Tetracycline
  1. Which anti-fungal drug is used for the treatment of systemic fungal infections?
  • A) Amphotericin B
  • B) Griseofulvin
  • C) Nystatin
  • D) Ketoconazole
  • Answer: A) Amphotericin B
  1. Which of the following drugs is used to treat influenza?
  • A) Acyclovir
  • B) Oseltamivir
  • C) Clindamycin
  • D) Miconazole
  • Answer: B) Oseltamivir
  1. Which of the following antibiotics is used to treat Clostridium difficile infections?
  • A) Clindamycin
  • B) Vancomycin
  • C) Azithromycin
  • D) Amoxicillin
  • Answer: B) Vancomycin
  1. Which of the following anti-infective drugs can cause a “Red Man Syndrome” reaction?
  • A) Penicillin
  • B) Vancomycin
  • C) Metronidazole
  • D) Rifampin
  • Answer: B) Vancomycin
  1. What type of infection is commonly treated with acyclovir?
  • A) Fungal infection
  • B) Bacterial infection
  • C) Viral infection
  • D) Parasitic infection
  • Answer: C) Viral infection
  1. Which of the following antibiotics should not be used in children under the age of 8 due to its potential to cause permanent tooth discoloration?
  • A) Azithromycin
  • B) Doxycycline
  • C) Erythromycin
  • D) Clindamycin
  • Answer: B) Doxycycline
  1. Which anti-infective drug is commonly prescribed to treat a viral infection like herpes simplex?
  • A) Acyclovir
  • B) Ciprofloxacin
  • C) Ceftriaxone
  • D) Amoxicillin
  • Answer: A) Acyclovir
  1. Which of the following is a common side effect of metronidazole?
  • A) Jaundice
  • B) Metallic taste
  • C) Kidney damage
  • D) Tachycardia
  • Answer: B) Metallic taste
  1. Which of the following anti-fungal agents is available as both oral and topical formulations?
  • A) Nystatin
  • B) Amphotericin B
  • C) Ketoconazole
  • D) Griseofulvin
  • Answer: C) Ketoconazole
  1. Which antibiotic is effective against methicillin-resistant Staphylococcus aureus (MRSA)?
  • A) Amoxicillin
  • B) Vancomycin
  • C) Penicillin
  • D) Erythromycin
  • Answer: B) Vancomycin
  1. Which class of drugs is used to treat infections caused by Plasmodium, the parasite responsible for malaria?
  • A) Antifungals
  • B) Antivirals
  • C) Antiprotozoals
  • D) Antibiotics
  • Answer: C) Antiprotozoals
  1. Which of the following anti-infective drugs is used to treat HIV infections?
  • A) Zidovudine
  • B) Isoniazid
  • C) Metronidazole
  • D) Rifampin
  • Answer: A) Zidovudine
  1. What is the primary action of the drug rifampin?
  • A) Inhibits bacterial cell wall synthesis
  • B) Inhibits protein synthesis
  • C) Inhibits RNA synthesis
  • D) Inhibits DNA synthesis
  • Answer: C) Inhibits RNA synthesis
  1. Which antibiotic is often used to treat syphilis?
  • A) Doxycycline
  • B) Penicillin G
  • C) Tetracycline
  • D) Amoxicillin
  • Answer: B) Penicillin G
  1. Which of the following is an adverse effect associated with the use of tetracyclines?
  • A) Renal failure
  • B) Photosensitivity
  • C) Hypertension
  • D) Tachycardia
  • Answer: B) Photosensitivity
  1. Which of the following anti-infective drugs can cause a disulfiram-like reaction when consumed with alcohol?
  • A) Metronidazole
  • B) Azithromycin
  • C) Amoxicillin
  • D) Rifampin
  • Answer: A) Metronidazole
  1. What is the mechanism of action of cephalosporins?
  • A) Inhibit protein synthesis
  • B) Inhibit cell wall synthesis
  • C) Inhibit DNA replication
  • D) Disrupt cell membranes
  • Answer: B) Inhibit cell wall synthesis
  1. Which of the following drugs is a common treatment for fungal infections of the skin?
  • A) Ketoconazole
  • B) Rifampin
  • C) Metronidazole
  • D) Amoxicillin
  • Answer: A) Ketoconazole
  1. Which of the following is an indication for the use of ciprofloxacin?
  • A) Fungal infection
  • B) Respiratory tract infection
  • C) Hepatitis
  • D) Parasitic infection
  • Answer: B) Respiratory tract infection
  1. Which anti-infective agent is contraindicated in patients with a history of seizure disorders?
  • A) Amoxicillin
  • B) Levofloxacin
  • C) Metronidazole
  • D) Penicillin
  • Answer: B) Levofloxacin
  1. Which of the following is a broad-spectrum antibiotic that is effective against both gram-positive and gram-negative bacteria?
  • A) Penicillin
  • B) Amoxicillin
  • C) Ciprofloxacin
  • D) Clindamycin
  • Answer: C) Ciprofloxacin

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